It's 1829 and young Englishwoman Isadora Byrnes arrives in America with a valise full of gold and a mysterious silver block. While trying to stay ahead of the shadowy organization trying to take the silver block from her, she finds herself in the middle of the violent conflict raging between the white settlers and the Cherokee people, finally culminating in the infamous Trail of Tears. Along the way, she experiences intense love and heartbreaking loss, all while carefully documenting her own story, along with the political and social events that motivate the conflict.
After the Trail of Tears, Isadora and her family continue on into a new and relatively unexplored area of the American Frontier known as the Rocky Mountains.
Isadora's story is interspersed with that of a modern Colorado woman, Isadora's descendant, Dora Baskin. She finds Isadora's journal and, while learning about the history of her ancestor, Dora also discovers that someone is still trying to find the mysterious silver block. And they are not above committing murder to get it.