It is hotter than hell in New Orleans and newly promoted NOPD Commander Jack Francoise is battling horrific crime in the Vieux Carre in the August heat. At Crescent City Medical Center's Psychiatric Pavilion, nurses are doling out Thorazine Slurpees and Geodon shots to some of the most criminally insane and viciously psychotic patients in the South. Alexandra Destephano, a registered nurse and legal counsel for CCMC, is troubled by safety issues in The Pavilion and enlists former husband, dashing surgeon Robert Bonnet to assist her in minimizing the dangers, but they are only aware of the ones they see. The situation escalates as the days become hotter and the nights become longer. Brutal beatings and murder are the order of the day and life in the Big Easy is clearly Uneasy.